Structural MRI

We currently focus on MRI measurements of brain atrophy, lesion load, and cortical thickness analysis in neurological patients, including those with Multiple Sclerosis (MS), Parkinson’s (PD) and Alzheimer’s diseases (AD), among others, as well as psychiatric patients (OCD), using automatic methods for white matter/grey matter atrophy quantification and regional localization, such as voxel-based morphometry (VBM).

A distinctive strength of our group is the implementation of extensive longitudinal neuroimaging studies across a broad spectrum of neurological disorders. By following patient cohorts over time, we are able to track progressive structural brain changes, evaluate the neuroanatomical correlates of clinical deterioration, and assess the effects of therapeutic interventions — including neuromodulation — on brain morphology. These longitudinal designs have been applied across conditions such as MS, PD, and AD, providing a comprehensive and dynamic view of disease-related neuroplasticity and treatment-induced changes at the neural level.